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Estrogen Receptor/ERR

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Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Products Related to Estrogen Receptor/ERR(175)

  • GC10002 structure
    GC10002Coumestrol
    CAS: 479-13-0
    Purity: >98.00%

    Coumestrol is a natural, orally active coumestan phytoestrogen. Coumestrol competitively binds estrogen receptor ERα (IC 50 =11nM) and ERβ (IC 50 =2nM) to regulate estrogen-responsive genes.

  • GC10139 structure
    GC10139Estradiol Cypionate
    CAS: 313-06-4
    Purity: >98.00%

    Estrogen receptor inhibitor

  • GC10389 structure
    GC10389ERB 041
    CAS: 524684-52-4
    Purity: >98.00%

    ERB 041 (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. ERB 041 displays >200-fold selectivity for ERβ over ERα. ERB 041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. ERB 041 induces ovarian cancer apoptosis.

  • GC10394 structure
    GC10394DY131
    CAS: 95167-41-2
    Purity: >98.00%

    An ERRβ/γ agonist

  • GC10558 structure
    GC10558GSK 4716
    CAS: 101574-65-6
    Purity: >98.00%

    estrogen-related receptors ERRβ and ERRγ agonist

  • GC10684 structure
    GC10684Zearalanone
    CAS: 5975-78-0
    Purity: >98.00%

    estrogen receptor agonist

  • GC10789 structure
    GC10789XCT790
    CAS: 725247-18-7
    Purity: >98.00%

    XCT790 is a potent and selective inverse agonist for ERRα with an IC 50 value of 0.37μM.

  • GC10852 structure
    GC10852Bazedoxifene acetate
    CAS: 198481-33-3
    Purity: >99.50%

    A selective estrogen receptor modulator

  • GC11215 structure
    GC11215Diethylstilbestrol
    CAS: 56-53-1
    Purity: >99.00%

    synthetic nonsteroidal estrogen

  • GC11282 structure
    GC11282β-Estradiol
    CAS: 50-28-2
    Purity: >99.50%

    Sex hormone

  • GC11425 structure
    GC11425Lasofoxifene (tartrate)
    CAS: 190791-29-8
    Purity: >99.50%

    third-generation, non-steroidal selective estrogen receptor modulator (SERM)

  • GC11544 structure
    GC11544Toremifene
    CAS: 89778-26-7
    Purity: >98%
  • GC11669 structure
    GC11669Tamoxifen Citrate
    CAS: 54965-24-1
    Purity: >99.50%

    Antiestrogen drug

  • GC11734 structure
    GC11734α-Zearalenol
    CAS: 36455-72-8
    Purity: >98.00%

    estrogen receptor agonist

  • GC11796 structure
    GC11796Estradiol valerate
    CAS: 979-32-8
    Purity: >99.00%

    Estradiol valerate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

  • GC11822 structure
    GC11822Erteberel (LY500307)
    CAS: 533884-09-2
    Purity: >98.00%

    Erteberel (LY500307) (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively.

  • GC11863 structure
    GC11863PHTPP
    CAS: 805239-56-9
    Purity: >98.00%

    PHTPP is a selective ERβ full antagonist with 36-fold selectivity for ERβ over ERα. PHTPP can selectively antagonize the ligand binding and transcriptional functions of ERβ, blocking its inhibitory effect on tumor cells, thereby promoting cell proliferation. PHTPP was used to verify ERβ function.

  • GC11996 structure
    GC11996Ospemifene
    CAS: 128607-22-7
    Purity: >99.50%

    non-hormonal selective estrogen receptor modulator (SERM)

  • GC12140 structure
    GC12140Endoxifen
    CAS: 112093-28-4
    Purity: >98%

    Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

  • GC12148 structure
    GC12148Ethinyl Estradiol
    CAS: 57-63-6
    Purity: >99.50%

    Ethinyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

  • GC12182 structure
    GC12182Estriol
    CAS: 50-27-1
    Purity: >99.00%

    Estriol is an agonist of estrogen receptors (ERα and ERβ) and G protein-coupled receptor 30 (GPR30) antagonist.

  • GC12644 structure
    GC12644Quinestrol
    CAS: 152-43-2
    Purity: >98.00%

    synthetic estrogen that is effective in hormone replacement therapy

  • GC12766 structure
    GC12766G-1
    CAS: 881639-98-1
    Purity: >99.50%

    G-1 is a selective and potent agonist of GPR30 with EC50 value about 2 nM.

  • GC13309 structure
    GC13309WAY 200070
    CAS: 440122-66-7
    Purity: >99.00%

    ERβ receptor agonist