GLPBio

ML67-33

Catalog No.: GC38555Purity:>99.00%
COASDSData Sheet
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.

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ML67-33
Cas No.: 1443290-89-8
5mgIn Stock
$108.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

ML67-33 activates K2P channels and mutants with EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively[1].

[1]. Bagriantsev SN, et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1443290-89-8
SMILES
CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14
Molecular Formula
C18H17Cl2N5
Molecular Weight
374.27
Solubility
DMSO : 100 mg/mL (267.19 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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