GLPBio

Histone H3K79Me1 (69-89) amide (human, mouse, rat, bovine) (trifluoroacetate salt)

Catalog No.: GC45481Purity:>95.00%Synonyms: Histone H3 (69-89) (Lys79me1) amide, Lys(Me1)79-Histone H3 (69-89) amide, RLVREIAQDF-K(Me1)-TDLRFQSSAV-NH2
COASDSData Sheet
 

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Histone H3K79Me1 (69-89) amide (human, mouse, rat, bovine) (trifluoroacetate salt)
250μgIn Stock
$373.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

Histone H3K79Me1 (69-89) amide is a peptide fragment of histone H3 that corresponds to amino acid residues 70-90 of the human histone H3.1 and H3.2 sequences. Methylation of lysine 79 on histone H3 is associated with active chromatin and the silencing of telomere-associated genes by silent information regulator (Sir) proteins.1 The conversion of H3K79Me1 to H3K79Me2/3 is associated with increased expression of mixed lineage leukemia (MLL) target genes, including Hoxa9.2

References
1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).
2. Deshpande, A.J., Deshpande, A., Sinha, A.U., et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell 26(6), 896-908 (2014).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
Histone H3 (69-89) (Lys79me1) amide, Lys(Me1)79-Histone H3 (69-89) amide, RLVREIAQDF-K(Me1)-TDLRFQSSAV-NH2
SMILES
OC(C(CO)=C(C=N1)CO)=C1C([2H])([2H])[2H].Cl
Molecular Formula
C110H182N34O32.XCF3COOH
Molecular Weight
2492.9
Solubility
Formic Acid: 1 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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