GLPBio

Taurohyocholic Acid

Catalog No.: GC45574Purity:>95.00%Synonyms: Tauro-γ-muricholic Acid
COASDSData Sheet
Taurohyocholic Acid is a taurine-conjugated bile acid derived from hyocholic acid, predominantly found in pig bile.

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Taurohyocholic Acid
Cas No.: 32747-07-2
5mgIn Stock
$122.00
1
10mgIn Stock
$219.00
1
25mgIn Stock
$486.00
1
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Description

Taurohyocholic Acid is a taurine-conjugated bile acid derived from hyocholic acid, predominantly found in pig bile[1]. Taurohyocholic Acid plays a crucial role in glucose homeostasis[2] and metabolic regulation[3]. It is also used in research of oncology[4] and end-stage renal disease (ESRD)[5] as a biomarker for predicting treatment efficacy.

Taurohyocholic Acid stimulate GLP-1 production and secretion in intestinal enteroendocrine STC-1 and NCI-H716 cells by promoting proglucagon transcription. In STC-1 and NCI-H716 cells, treatment with 25µM Taurohyocholic Acid for 1 hour significantly increased GLP-1 secretion, and a 24-hour incubation further promoted proglucagon transcription and GLP-1 production[6].

References:
[1]. Fang W, Wen X, Meng Q, et al. Alteration in bile acids profile in Large White pigs during chronic heat exposure. J Therm Biol. 2019 Aug;84:375-383. doi: 10.1016/j.jtherbio.2019.07.027. Epub 2019 Jul 26. PMID: 31466777.
[2]. Cheng Z, Liu G, Zhang X, et al. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model. Med Sci Monit. 2018 Oct 9;24:7206-7212. doi: 10.12659/MSM.912429. PMID: 30298865; PMCID: PMC6192455.
[3]. Zheng X, Chen T, Zhao A, et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nat Commun. 2021 Mar 5;12(1):1487. doi: 10.1038/s41467-021-21744-w. PMID: 33674561; PMCID: PMC7935989.
[4]. Chen Y, Wang Y, Lei J, et al. Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma. Front Pharmacol. 2024 Feb 23;15:1364924. doi: 10.3389/fphar.2024.1364924. PMID: 38464731; PMCID: PMC10920247.
[5]. Chen WY, Zhang JH, Chen LL, et al. Bioactive metabolites: a clue to the link between MASLD and CKD? Clin Mol Hepatol. 2024 Oct 21. doi: 10.3350/cmh.2024.0782. Epub ahead of print. PMID: 39428978.
[6]. Zheng X, Chen T, Jiang R, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7. doi: 10.1016/j.cmet.2020.11.017. Epub 2020 Dec 17. PMID: 33338411.

Protocol

Cell experiment [1]:

Cell lines

STC-1

Preparation Method

The STC-1 cell were plated into 24 well-plates with an initial cell density of 2*105 cells/well, treated with 25µM Taurohyocholic Acid for 1h. The cell media was removed from the cells, centrifuged at 2,000g for 10min to remove cell debris and the supernatant was collected. An GLP-1 ELISA kit was used to measure GLP-1.

Reaction Conditions

25µM, 1h

Applications

Taurohyocholic Acid can upregulated GLP-1 secretion in STC-1 cells.

References:
[1]. Zheng X, Chen T, Jiang R, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7. doi: 10.1016/j.cmet.2020.11.017. Epub 2020 Dec 17. PMID: 33338411.

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
32747-07-2
Synonyms
Tauro-γ-muricholic Acid
Chemical Name
2-[[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(O)(=O)=O)=O)([H])C1
Molecular Formula
C26H45NO7S
Molecular Weight
515.7
Solubility
20mg/mL in ethanol, or DMSO, 30mg/mL in DMF
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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