Taurohyocholic Acid (Synonyms: Tauro-γ-muricholic Acid) |
| Catalog No.GC45574 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 32747-07-2
Sample solution is provided at 25 µL, 10mM.
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Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .[1] THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.[2] It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.[3] THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.[4]
References
[1]. Wahlstr•m, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[2]. Juste, C., Catala, I., Henry, R., et al. Influence of bile salt molecular species on cholesterol crystallization from supersaturated model biles. Biochim. Biophys. Acta. 1254(1), 89-97 (1995).
[3]. Scholmerich, J., Kitamura, S., Baumgartner, U., et al. Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liver. Res. Exp. Med. (Berl.) 190(2), 121-129 (1990).
[4]. Wang, X., Xie, G., Zhao, A., et al. Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosis. J. Proteome Res. 15(4), 1126-1134 (2016).
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