D-Glucosamine 6-phosphate is an endogenous metabolite, a phosphorylated form of glucosamine, which can be synthesized by glutamine fructose-6-phosphate aminotransferase (GFAT)[1, 2]. D-Glucosamine 6-phosphate is a key intermediate metabolite in the hexosamine biosynthesis pathway (HBP) in cells and is involved in the production of N-acetylglucosamine (GlcNAc) and UDP-GlcNAc[3]. D-Glucosamine 6-phosphate can be used in the research of diabetes and osteoarthritis[4, 5].
References:
[1] Weimer S, Priebs J, Kuhlow D, et al. D-Glucosamine supplementation extends life span of nematodes and of ageing mice[J]. Nature communications, 2014, 5(1): 3563.
[2] Kato N, Dasgupta R, Smartt C T, et al. Glucosamine: fructose‐6‐phosphate aminotransferase: gene characterization, chitin biosynthesis and peritrophic matrix formation in Aedes aegypti[J]. Insect molecular biology, 2002, 11(3): 207-216.
[3] Paneque A, Fortus H, Zheng J, et al. The hexosamine biosynthesis pathway: regulation and function[J]. Genes, 2023, 14(4): 933.
[4] Miszkiel A, Wojciechowski M. Long range molecular dynamics study of interactions of the eukaryotic glucosamine-6-phosphate synthase with fructose-6-phosphate and UDP-GlcNAc[J]. Journal of Molecular Graphics and Modelling, 2017, 78: 14-25.
[5] Salazar J, Bello L, Chávez M, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism[J]. Arthritis, 2014, 2014(1): 432463.