MMK1 (trifluoroacetate salt) (Synonyms: LESIFRSLLFRVM, Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met) |
Catalog No.GC47695
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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MMK1 is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1).1 MMK1 induces calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = <2 nM) but not in CHO cells expressing Gα16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner.2 MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes. Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.3
1.Klein, C., Paul, J.I., SauvÉ, K., et al.Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeastNat. Biotechnol.16(13)1334-1337(1998) 2.Hu, J.Y., Le, Y., Gong, W., et al.Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1J. Leukoc. Biol.70(1)155-161(2001) 3.Zhao, H., Sonada, S., Yoshikawa, A., et al.Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptorsPeptides8316-20(2016)
| Cas No. | N/A | SDF | |
| Synonyms | LESIFRSLLFRVM, Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met | ||
| Canonical SMILES | CC(C)C[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC2=CC=CC=C2)=O)([H])[C@@H](C)CC)=O)=O)=O)N[H].OC(C(F)(F)F)=O | ||
| Formula | C75H123N19O18S .XCF3COOH | M.Wt | 1611 |
| Solubility | Methanol: soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 620.7 μL | 3.1037 mL | 6.2073 mL |
| 5 mM | 124.1 μL | 620.7 μL | 1.2415 mL |
| 10 mM | 62.1 μL | 310.4 μL | 620.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)