8-Epixanthatin is a light-induced growth inhibitor that regulates the phototropic curvature in sunflower hypocotyls [1]. 8-Epixanthatin inhibits auxin-induced growth of sunflower hypocotyl and oat coleoptile sections as well as the elongation of cress roots [2]. 8-Epixanthatin can be used as an internal reference to develop HPLC–UV or HPLC-MS/MS measurements for the examination of related compounds in plants[3].
In vitro, 8-Epixanthatin treatment for 12 hours significantly reduced the level of p-STAT3-Y705 in DU145 cells, with an IC50 value of 3.2μM[4].
In vivo, 8-Epixanthatin treatment via intraperitoneal injection at a dose of 50mg/kg, 5 times a week for 25 days, significantly inhibited tumor growth in the DU145 mouse xenograft model without affecting body weight[4].
References:
[1] Kühne M, Hamscher G, Körner U, et al. Formation of anhydrotetracycline during a high-temperature treatment of animal-derived feed contaminated with tetracycline[J]. Food chemistry, 2001, 75(4): 423-429.
[2] Yokotani-Tomita K, Kato J, Kosemura S, et al. Light-induced auxin-inhibiting substance from sunflower seedlings[J]. Phytochemistry, 1997, 46(3): 503-506.
[3] Spring O, Schmauder K, Lackus N D, et al. Spatial and developmental synthesis of endogenous sesquiterpene lactones supports function in growth regulation of sunflower[J]. Planta, 2020, 252(1): 2.
[4] Lee Y J, Choi J, Yoon Y J, et al. 8‐Epi‐xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation[J]. Phytotherapy Research, 2021, 35(3): 1508-1520.