GLPBio

Glutathione Peroxidase

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Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Products Related to Glutathione Peroxidase(48)

  • GB10587 structure
    GB10587Gingerenone A
    CAS: 128700-97-0
    Purity: >98.00%

    Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM.

  • GC12431 structure
    GC12431RSL3
    CAS: 1219810-16-8
    Purity: >98.00%

    RSL3, a GPX4 inhibitor, triggers lipid peroxidation and decreases GPX4 expression.

  • GC18256 structure
    GC18256PF-06281355
    CAS: 1435467-38-1
    Purity: >99.50%

    PF-06281355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.

  • GC18705 structure
    GC18705ML-210
    CAS: 1360705-96-9
    Purity: >98.00%

    ML-210 is a prodrug that selectively inhibits GPX4 covalently with an EC 50 of 30nM.

  • GC19285 structure
    GC19285PF-06282999
    CAS: 1435467-37-0
    Purity: >99.00%

    PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.

  • GC19706 structure
    GC19706Propacetamol hydrochloride
    CAS: 66532-86-3
    Purity: >98%
  • GC20061 structure
    GC20061ClAP (Alkaline Phosphatase, Calf intestinal)
    CAS: 9001-78-9

    ClAP (Alkaline Phosphatase, Calf intestinal) is a membrane-bound glycoprotein that hydrolyzes a broad range of monophosphate esters at alkaline pH.

  • GC20109 structure
    GC20109Cefotiam hexetil hydrochloride
    CAS: 95789-30-3
    Purity: >98%

    Cefotiam hexetil hydrochloride (CTM-HE) is an oral third-generation cephalosporin, which is a prodrug of cefotiam, but has no anti-bacterial property. Cefotiam is an antibiotic.

  • GC30237 structure
    GC30237Verdiperstat (AZD3241)
    CAS: 890655-80-8
    Purity: >99.50%

    Verdiperstat (AZD3241) (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

  • GC30783 structure
    GC30783AZD5904
    CAS: 618913-30-7
    Purity: >99.50%

    AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

  • GC31882 structure
    GC31882Tinoridine hydrochloride (Y-3642 hydrochloride)
    CAS: 25913-34-2
    Purity: >98.00%

    Tinoridine hydrochloride (Y-3642 hydrochloride) is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.

  • GC35139 structure
    GC351394-Methylesculetin
    CAS: 529-84-0
    Purity: >95.00%

    4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities.

  • GC36650 structure
    GC36650MPO-IN-28
    CAS: 37836-90-1
    Purity: >98.00%

    MPO-IN-28 (Compound 28) is a myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.

  • GC40555 structure
    GC40555Tiopronin
    CAS: 1953-02-2
    Purity: >98.00%

    Tiopronin is an antioxidant that has diverse biological activities.

  • GC41151 structure
    GC41151Decursinol angelate
    CAS: 130848-06-5
    Purity: >98.00%

    Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

  • GC43448 structure
    GC43448Didymin
    CAS: 14259-47-3
    Purity: >98.00%

    Didymin is a flavonoid that has been found in citrus fruits with diverse biological activities.

  • GC60263 structure
    GC60263N-Acetyl lysyltyrosylcysteine amide
    CAS: 1287585-40-3
    Purity: >98%

    N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO).

  • GC63729 structure
    GC63729GPX4-IN-3
    CAS: 2761004-85-5
    Purity: >99.50%

    GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.

  • GC63975 structure
    GC63975Acanthoside B
    CAS: 7374-79-0
    Purity: >98%

    Acanthoside B is a potential bioactive lignan with anti-inflammatory and anti-amnesic activities.

  • GC64119 structure
    GC64119Saponarin
    CAS: 20310-89-8
    Purity: >98%

    Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities.

  • GC67918 structure
    GC67918MPO-IN-1
    CAS: 2471981-21-0
    Purity: >98%
  • GC68468 structure
    GC68468MPO-IN-3
    CAS: 1435469-45-6
    Purity: >98%
  • GC69468 structure
    GC69468Mitiperstat
    CAS: 1933460-19-5
    Purity: >97.00%

    Mitiperstat (AZD4831) is an effective inhibitor of myeloperoxidase (MPO). Mitiperstat is particularly useful in the prevention of cardiovascular diseases such as heart failure and coronary artery disease-related diseases (information extracted from patent US20160152623A1).

  • GC71917 structure
    GC71917Moracin N
    CAS: 135248-05-4
    Purity: >99.00%

    Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf.