GLPBio

Guanylate Cyclase

GC (guanylyl cyclaese) converts GTP into cGMP and pyrophosphate. sGC (soluble GC) is a nitric oxide receptor and pGC (transmembrance GC) is a natriiuritic peptide receptor. Its major functions include cell hyperplasia,hypertrophy, cell differentiation and tumor progression etc.

Products Related to Guanylate Cyclase (29)

  • GC10192 structure
    GC10192BAY 41-2272
    CAS: 256376-24-6
    Purity: >99.50%

    Activator of soluble guanylyl cyclase (sGC)

  • GC10962 structure
    GC10962Cinaciguat
    CAS: 329773-35-5
    Purity: >99.00%

    An activator of sGC

  • GC11361 structure
    GC11361Ataciguat
    CAS: 254877-67-3
    Purity: >98.00%

    Ataciguat is a nitric oxide-independent soluble guanylate cyclase (sGC) activator.

  • GC11426 structure
    GC11426BAY 41-8543
    CAS: 256498-66-5
    Purity: >99.50%

    heme-dependent stimulator of soluble guanylate cyclase (sGC)

  • GC12887 structure
    GC12887Riociguat
    CAS: 625115-55-1
    Purity: >99.50%

    A stimulator of soluble guanylate cyclase

  • GC13857 structure
    GC13857LY83583
    CAS: 91300-60-6
    Purity: >99.00%

    LY83583 is a membrane-permeable soluble guanylate cyclase (sGC) inhibitor.

  • GC16406 structure
    GC16406YC 1
    CAS: 170632-47-0
    Purity: >99.00%

    Lificiguat (YC-1) is a no-dependent soluble guanylyl cyclase(sGC) activator and a Hypoxia-inducible faction-1alpha (HIF-1alpha) inhibitor.

  • GC16975 structure
    GC16975NS 2028
    CAS: 204326-43-2
    Purity: >99.50%

    soluble guanylyl cyclase (sGC) inhibitor

  • GC19459 structure
    GC19459Cinaciguat hydrochloride
    CAS: 646995-35-9
    Purity: >99.50%

    Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.

  • GC30016 structure
    GC30016Linaclotide
    CAS: 851199-59-2
    Purity: >98.00%

    A peptide agonist of the guanylate cyclase C receptor

  • GC30051 structure
    GC30051Methylene Blue (Basic Blue 9)
    CAS: 61-73-4
    Purity: >99.00%

    Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor.

  • GC32472 structure
    GC32472Vericiguat (BAY1021189)
    CAS: 1350653-20-1
    Purity: >98.00%

    Vericiguat (BAY1021189) is an oral soluble guanylate cyclase (sGC) stimulant and an inhibitor of breast cancer resistance protein (IC 50 = 20µM) as well as OATP1B1 and 1B3 (approximate IC 50 of 16 and 30µM, respectively).

  • GC32493 structure
    GC32493Nelociguat (BAY60-4552)
    CAS: 625115-52-8
    Purity: >99.50%

    Nelociguat (BAY60-4552) (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

  • GC33898 structure
    GC33898Plecanatide acetate
    CAS: 1075732-84-1
    Purity: >99.00%

    Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist.

  • GC34045 structure
    GC34045(4-Acetamidocyclohexyl) nitrate (BM121307)
    CAS: 137213-91-3
    Purity: >98%

    (4-Acetamidocyclohexyl) nitrate (BM121307) (BM121307) is a guanylate cyclase activator.

  • GC36801 structure
    GC36801Olinciguat
    CAS: 1628732-62-6
    Purity: >98.00%

    Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

  • GC39603 structure
    GC39603Methylene blue trihydrate
    CAS: 7220-79-3
    Purity: >99.00%

    Methylene blue trihydrate (C.

  • GC61604 structure
    GC61604Guanylin(human) TFA
    Purity: >97.00%

    Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator.

  • GC62616 structure
    GC62616MGV354
    Purity: >98%

    MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

  • GC63294 structure
    GC63294MM 419447
    CAS: 1092457-78-7
    Purity: >99.00%

    MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist.

  • GC64490 structure
    GC64490(Rac)-MGV354
    CAS: 1852495-86-3
    Purity: >99.00%

    (Rac)-MGV354 is the racemate of MGV354.

  • GC65051 structure
    GC65051BAY 60-2770
    CAS: 1027642-43-8
    Purity: >98%

    BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator.

  • GC65182 structure
    GC65182Zagociguat
    CAS: 2201048-82-8
    Purity: >99.00%

    Zagociguat is the stimulator of soluble guanylate cyclase.

  • GC65192 structure
    GC65192Runcaciguat
    CAS: 1402936-61-1
    Purity: >99.00%

    Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.