GLPBio

Gypsogenin

Catalog No.: GC26662Purity:>98.00%
COASDSData Sheet
Gypsogenin is a well-known natural saponin which has marked anticancer effects towards various types of cancer cell lines.

Products are for research use only. Not for human use. We do not sell to patients.

Gypsogenin
Cas No.: 639-14-5
1mgIn Stock
$86.00
1
5mgIn Stock
$218.00
1
10mgIn Stock
$323.00
1
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Description

Gypsogenin is a well-known natural saponin which has marked anticancer effects towards various types of cancer cell lines [1]. Gypsogenin can inhibit the growth and metastasis of Lewis lung cancer and triggers apoptosis by increasing Bax levels and possesses anticancer activities against L1210, CCER-CEM and Ls174T cancer cells [2]. Gypsogenin derivatives possess great potential as important pharmacophores.

Gypsogenin (0.1, 1, 10 and 100μM; 72h) displayed good cytotoxicity in the low concentration for several cancer cells (MCF-7, HeLa, Jurkat and K562), the values of IC50 ranged from 3.25 to 13.68μM [1]. Gypsogenin (5, 10, 20 and 40μM; 72h) showed a strong antiproliferative effect, with an IC50 between 5 and 10μM on HL-60 cells [3].

Gypsogenin (5.0, 7.5, 10.0mg/kg; 8d; i.p.) reduced the tumor weight and showed a preliminary anti-metastatic role on Lewis lung cancer in C57BL/6J mice [2].

References:
[1] Emirdağ S, Ulusoy N G, Aksel M. Design, synthesis and biological evaluation of novel gypsogenin derivatives as potential anticancer and antimicrobial agents [J]. Chemistry & biodiversity, 2024, 21(6): e202400471.
[2] Tian G, Zhou L, Zhong Y, et al. Experimental studies of the therapeutic effect of Gypsophila oldhamiana gypsogenin on Lewis lung cancer in mice [J]. Chinese Journal of Clinical Oncology, 2008, 5(3): 206-210.
[3] Ozturk S E, Babahan I, Ozmen A. Synthesis, characterization and in vitro anti-neoplastic activity of gypsogenin derivatives [J]. Bioorganic chemistry, 2014, 52/54: 15-23.

Protocol

Cell experiment [1]:

Cell lines

HeLa, MCF-7, K562 and Jurkat cell lines

Preparation Method

Gypsogenin was dissolved in the culture medium with 1% DMSO to give various concentrations (0.1, 1, 10, and 100μM, respectively). The resulted solutions were subsequently added to cell culture medium. Control group contained supplemented media with 1% DMSO. The cytotoxic effect of Gypsogenin was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazolium bromide (MTT) assay.

Reaction Conditions

0.1, 1, 10, and 100μM; 72h

Applications

Gypsogenin displayed good cytotoxicity for several cancer cells and the values of IC50 ranged from 3.25 to 13.68μM.
Animal experiment [2]:

Animal models

Male inbred C57BL/6J mice

Preparation Method

The mice inoculated with a solid tumor (Lewis lung cancer) were received a high, medium or low dose of Gypsogenin (10.0, 7.5, 5.0mg/kg) for 8d. After the mice were dissected, the tumors were removed, cleaned, weighed and a tumor control rate calculated.

Dosage form

5.0, 7.5, 10.0mg/kg; 8d; i.p.

Applications

Gypsogenin reduced the tumor weight and the tumor control rate was 49.6% in the high-dose group.

References:
[1] Emirdağ S, Ulusoy N G, Aksel M. Design, synthesis and biological evaluation of novel gypsogenin derivatives as potential anticancer and antimicrobial agents [J]. Chemistry & biodiversity, 2024, 21(6): e202400471.
[2] Tian G, Zhou L, Zhong Y, et al. Experimental studies of the therapeutic effect of Gypsophila oldhamiana gypsogenin on Lewis lung cancer in mice [J]. Chinese Journal of Clinical Oncology, 2008, 5(3): 206-210

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
639-14-5
SMILES
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@@](C)(C=O)[C@]3([H])CC[C@@]12C)C(O)=O
Molecular Formula
C30H46O4
Molecular Weight
470.68
Solubility
DMSO: 27.5 mg/ml (58.42 mM)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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