HIV Protease
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Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.
Products Related to HIV Protease(35)
- GC10240Atazanavir sulfate (BMS-232632-05)CAS: 229975-97-7Purity: >99.50%
An inhibitor of HIV-1 protease
- GC11974Pepstatin ACAS: 26305-03-3Purity: >98.50%
Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.
- GC17709NelfinavirCAS: 159989-64-7Purity: >99.00%
Nelfinavir is a selective, nonpeptidic competitive inhibitor of HIV-1 protease. Nelfinavir shows good in vitro activity against HIV-1 strains.
- GC33968DPC-681 (DPH-153893)CAS: 284661-68-3Purity: >99.50%
DPC-681 (DPH-153893) is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.
- GC36116Ganoderic acid BCAS: 81907-61-1Purity: >98.00%
A triterpenoid with diverse biological activities
- GC36120GanodermanondiolCAS: 107900-76-5Purity: >98%
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum.
- GC36310Indinavir sulfateCAS: 157810-81-6Purity: >99.50%
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR.
- GC36333Isoescin IACAS: 219944-39-5Purity: >98.50%
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis.
- GC36871Pepstatin AmmoniumPurity: >99.50%
Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10240 | Atazanavir sulfate (BMS-232632-05) | 229975-97-7 | >99.50% | |
An inhibitor of HIV-1 protease | ||||
| GC10794 | BMS-626529 | 701213-36-7 | >99.00% | |
An HIV-1 attachment inhibitor | ||||
| GC11300 | Fosamprenavir Calcium Salt | 226700-81-8 | >98.00% | |
A prodrug form of amprenavir | ||||
| GC11974 | Pepstatin A | 26305-03-3 | >98.50% | |
Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes. | ||||
| GC12945 | Atazanavir | 198904-31-3 | >98% | |
An inhibitor of HIV-1 protease | ||||
| GC13716 | Lopinavir | 192725-17-0 | >99.00% | |
A potent HIV-1 protease inhibitor | ||||
| GC14084 | Nelfinavir Mesylate | 159989-65-8 | >99.00% | |
An HIV-1 protease inhibitor | ||||
| GC14152 | Amprenavir (agenerase) | 161814-49-9 | >98.00% | |
A selective HIV protease inhibitor | ||||
| GC14454 | Tipranavir | 174484-41-4 | >98.00% | |
A nonpeptidic HIV protease inhibitor | ||||
| GC15335 | Saquinavir | 127779-20-8 | >99.00% | |
| GC15785 | Saquinavir mesylate | 149845-06-7 | >98.50% | |
An HIV protease inhibitor | ||||
| GC16602 | Darunavir | 206361-99-1 | >99.50% | |
An HIV-1 protease inhibitor | ||||
| GC17303 | Ritonavir | 155213-67-5 | >99.50% | |
An HIV protease inhibitor | ||||
| GC17709 | Nelfinavir | 159989-64-7 | >99.00% | |
Nelfinavir is a selective, nonpeptidic competitive inhibitor of HIV-1 protease. Nelfinavir shows good in vitro activity against HIV-1 strains. | ||||
| GC17942 | Darunavir Ethanolate | 635728-49-3 | >99.50% | |
nonpeptidic HIV protease inhibitor | ||||
| GC32013 | L-689502 | 138483-63-3 | >98% | |
L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM. | ||||
| GC32327 | PNU-103017 | 166335-18-8 | >98% | |
PNU-103017 is an HIV protease inhibitor. | ||||
| GC33968 | DPC-681 (DPH-153893) | 284661-68-3 | >99.50% | |
DPC-681 (DPH-153893) is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. | ||||
| GC36116 | Ganoderic acid B | 81907-61-1 | >98.00% | |
A triterpenoid with diverse biological activities | ||||
| GC36120 | Ganodermanondiol | 107900-76-5 | >98% | |
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum. | ||||
| GC36309 | Indinavir | 150378-17-9 | >98% | |
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. | ||||
| GC36310 | Indinavir sulfate | 157810-81-6 | >99.50% | |
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. | ||||
| GC36333 | Isoescin IA | 219944-39-5 | >98.50% | |
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. | ||||
| GC36871 | Pepstatin Ammonium | - | >99.50% | |
Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. | ||||