GLPBio

Hydroxy-PEG2-acid

Catalog No.: GC60921Purity:>98%
COASDSData Sheet
Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Products are for research use only. Not for human use. We do not sell to patients.

Hydroxy-PEG2-acid
Cas No.: 1334286-77-9
50mgIn Stock
$9.00
1
100mgIn Stock
$16.00
1
250mgIn Stock
$29.00
1
500mgIn Stock
$55.00
1
1gIn Stock
$99.00
1
5gIn Stock
$419.00
1
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical Properties

CAS No.
1334286-77-9
SMILES
OC(CCOCCOCCO)=O
Molecular Formula
C7H14O5
Molecular Weight
178.18
Solubility
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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