Viral Diseases

BMS-433771 dihydrochloride hydrate is an effective inhibitor of respiratory syncytial virus (RSV) with oral activity. It is effective against both group A and B RSV, with an EC50 average of 20 nM. BMS-433771 dihydrochloride hydrate can be used for research on respiratory diseases.

Clemastanin B is a lignin that has strong anti-influenza activity by inhibiting virus proliferation, preventing and blocking virus attachment. Clemastanin B targets the internalization of viruses, uncoating or ribonucleoprotein (RNP) export from the cell nucleus. It also has antioxidant and anti-inflammatory activities.

Clesrovimab (MK1654) is a fully human monoclonal antibody against respiratory syncytial virus fusion (RSV F) glycoprotein. Clesrovimab has the potential to study respiratory syncytial virus infections.

Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is a twelve-peptide rich in arginine that can penetrate cells and is a derivative of HIV-1 transactivator protein.

EIDD-2749 (4'-Fluorouridine) is an orally effective RdRp inhibitor. It can effectively inhibit the replication of RSV and SARS-CoV-2. EIDD-2749 also exhibits activity against HCV and lymphocytic choriomeningitis virus (LCMV). EIDD-2749 is a promising oral candidate for COVID-19 research, as well as for other RNA viruses.

Glycolithocholic acid 3-sulfate (SLCG) is a metabolite of bile acids and glycochenodeoxycholic acid. Glycolithocholic acid 3-sulfate inhibits the replication of HIV-1. It can be used for research on HIV infection and gallbladder disease.

HIV-1 inhibitor-45 (compound IA-6) is an effective inhibitor of HIV-1 RNase H, with an IC50 of 0.067 μM. HIV-1 inhibitor-45 exhibits antiviral activity.

Isatin-beta-thiosemicarbazone is an effective anti-poxvirus agent (including monkeypox virus, variola virus, cowpox virus, etc.). Isatin-beta-thiosemicarbazone is also an effective inhibitor of herpes simplex virus (HSV). Isatin-beta-thiosemicarbazone has antiviral activity against both HSV-1 and HSV-2.

Nirsevimab (MEDI8897) is a recombinant human respiratory syncytial virus (RSV) monoclonal antibody with a modified Fc region that extends its half-life. Nirsevimab has an affinity for RSV-B, with a Kd value of 1.5 nM. Nirsevimab can be used in RSV research.

Suptavumab (REGN2222) is a human monoclonal antibody that can bind and block the conserved epitopes on both RSV A and B subtypes. Suptavumab can be used for research on RSV infection.

Trecovirsen (GEM91) is an antisense oligonucleotide that targets the HIV gag gene.

Clathrin-IN-1 is a selective clathrin-mediated endocytosis (CME) inhibitor.

SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation.

Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses.

JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor.

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM.

Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of Emtricitabine triphosphate .

Dolutegravir-d3 is the deuterium labeled Dolutegravir.

Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata.

EFdA-TP tetrasodium is a potent nucleoside reverse transcriptase (RT) inhibitor.

Fipravirimat dihydrochloride is a potent HIV-1 inhibitor.

Onradivir is a potent anti-influenza virus agent.

JNJ-8003 is a potent inhibitor of RSV Polymerase.

PYR01 is a potent HIV-1 nonnucleoside reverse transcriptase inhibitor.