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HIV Integrase

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Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

Products Related to HIV Integrase(28)

  • GC10572 structure
    GC10572Equisetin
    CAS: 57749-43-6
    Purity: >98%

    HIV-1 integrase inhibitor

  • GC11923 structure
    GC11923BMS-707035
    CAS: 729607-74-3
    Purity: >99.50%
  • GC11956 structure
    GC11956Raltegravir (MK-0518)
    CAS: 518048-05-0
    Purity: >98.00%
  • GC12339 structure
    GC12339Ivermectin
    CAS: 70288-86-7
    Purity: >98.00%

    Ivermectin is a macrolide endectocide with activity against both endoparasites and ectoparasites.

  • GC12998 structure
    GC12998HIV-1 integrase inhibitor
    CAS: 544467-07-4
    Purity: >98%
  • GC14057 structure
    GC14057GSK1349572 sodiuM salt
    CAS: 1051375-19-9
    Purity: >99.00%

    GSK1349572 sodiuM salt (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer.

  • GC14084 structure
    GC14084Nelfinavir Mesylate
    CAS: 159989-65-8
    Purity: >99.00%

    An HIV-1 protease inhibitor

  • GC14466 structure
    GC14466Fluorouracil (Adrucil)
    CAS: 51-21-8
    Purity: >98.00%

    Fluorouracil (Adrucil) (5-FU) is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen.

  • GC14996 structure
    GC14996Elvitegravir (GS-9137)
    CAS: 697761-98-1
    Purity: >99.50%

    An inhibitor of HIV-1 integrase

  • GC15036 structure
    GC15036Raltegravir potassium salt
    CAS: 871038-72-1
    Purity: >98.00%

    Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

  • GC15561 structure
    GC15561MK-2048
    CAS: 869901-69-9
    Purity: >98%
  • GC16215 structure
    GC16215GSK744 (S/GSK1265744)
    CAS: 1051375-10-0
    Purity: >98.00%

    GSK744 (S/GSK1265744) (GSK-1265744) is a orally active and long-acting HIV integrase inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively.

  • GC17906 structure
    GC17906S/GSK1349572
    CAS: 1051375-16-6
    Purity: >98.00%

    A potent inhibitor of HIV integrase

  • GC18016 structure
    GC18016Salicylanilide
    CAS: 87-17-2
    Purity: >99.00%

    Antiviral,antibacterial,antifungal reagent

  • GC32060 structure
    GC32060Bictegravir (GS-9883)
    CAS: 1611493-60-7
    Purity: >99.50%

    Bictegravir (GS-9883) is an integrase strand transfer inhibitor (INSTI) used for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.

  • GC34961 structure
    GC34961(±)-BI-D
    CAS: 1416258-16-6
    Purity: >98.00%

    (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.

  • GC35510 structure
    GC35510BI 224436
    CAS: 1155419-89-8
    Purity: >98.00%

    BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.

  • GC36233 structure
    GC36233HIV-1 integrase inhibitor 2
    CAS: 957890-42-5
    Purity: >99.00%

    HIV-1 integrase inhibitor 2 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase.

  • GC36234 structure
    GC36234HIV-1 integrase inhibitor 3
    CAS: 1638504-56-9
    Purity: >98%

    HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.

  • GC36235 structure
    GC36235HIV-1 integrase inhibitor 4
    CAS: 1638504-66-1
    Purity: >98%

    HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.

  • GC45494 structure
    GC45494Lavendustin B
    CAS: 125697-91-8
    Purity: >98.00%

  • GC60978 structure
    GC60978L-Chicoric Acid
    CAS: 70831-56-0
    Purity: >99.50%

    A dicaffeoyl ester with diverse biological activities

  • GC61576 structure
    GC61576Robinetin
    CAS: 490-31-3
    Purity: >97.00%

    Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity.

  • GC63399 structure
    GC63399HIV-1 integrase inhibitor 8
    CAS: 1568-80-5
    Purity: >98%

    HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.