ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50 s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].
In Vitro, ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].
References:
[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.
In Vitro, ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].
References:
[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.