β-CGRP, human (Human β-CGRP) |
| カタログ番号GC33595 |
β-CGRP、ヒト（Human β-CGRP）はカルシトニンペプチドの一種であり、カルシトニン受容体様受容体（CRLR）とレセプター活性修飾タンパク質（RAMP）の複合体を介して作用し、細胞内でのCRLR/RAMP1およびCRLR/RAMP2に対するIC50はそれぞれ1 nMおよび300 nMです。
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Cas No.: 101462-82-2
Sample solution is provided at 25 µL, 10mM.
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β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.
β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].
[1]. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. [2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.
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