CAY10701 |
カタログ番号GC40890 |
CAY10701は、マイクロチューブル形成を防止し、HeLaおよびMCF-7細胞の増殖を阻害する7-デアザヒポキサンチンアナログです(GI50値はそれぞれ22nMおよび38nM)。
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Cas No.: 1616967-52-2
Sample solution is provided at 25 µL, 10mM.
CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.
Average Rating: 5
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