Curvularin (Synonyms: (-)-Curvularin, (S)-Curvularin, NSC 166071) |
| カタログ番号GC18864 |
真菌の代謝産物であり、Curvularia lunata から自然に分離された強力なマイコトキシンであるクルブラリンは、サイトカイン誘導性一酸化窒素シンターゼ (iNOS) を 9.5 μM の IC50 で阻害します 。
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Cas No.: 10140-70-2
Sample solution is provided at 25 µL, 10mM.
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Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].
References:
[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122.
[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91.
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