Taurodeoxycholic acid sodium hydrate |
カタログ番号GC37745 |
胆汁酸であるタウロデオキシクロ酸ナトリウム水和物(タウロデオキシコール酸ナトリウム一水和物)は、肝臓でコレステロールから合成される両親媒性界面活性剤分子です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110026-03-4
Sample solution is provided at 25 µL, 10mM.
Taurodeoxycholic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1]. Caspase-12
Taurodeoxycholic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington's disease[2].
[1]. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. [2]. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.
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