LAS-31180 |
| カタログ番号GC32529 |
LAS-31180 はホスホジエステラーゼ 3 の阻害剤であり、正の強心作用と血管拡張作用があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137338-43-3
Sample solution is provided at 25 µL, 10mM.
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LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].
[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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