VU 6008667 |
| カタログ番号GC37928 |
VU 6008667 は、M5 NAM の選択的ネガティブ アロステリック モジュレーターであり、IC50 は、ヒト M5 およびラット M5 に対してそれぞれ 1.2 μM および 1.6 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2092923-21-0
Sample solution is provided at 25 µL, 10mM.
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VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].
[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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