YF-2 |
| カタログ番号GC31099 |
YF-2 は、高度に選択的な血液脳関門透過性ヒストン アセチルトランスフェラーゼ活性化因子であり、海馬で H3 をアセチル化し、CBP、PCAF、および GCN5 の EC50 はそれぞれ 2.75 μM、29.04 μM、および 49.31 μM であり、HDAC に影響を示さない.
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Cas No.: 1311423-89-8
Sample solution is provided at 25 µL, 10mM.
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YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].
[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.
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