MPT0B390 |
| カタログ番号GC64729 |
MPT0B390 は、強力な HDAC 阻害能力を持つアリールスルホンアミドベースの誘導体です。 TIMP3 インデューサーである MPT0B390 は、腫瘍の成長、転移、および血管新生を阻害します。 MPT0B390 は、ヒト結腸癌細胞株 HCT116 に対して 0.03 μM の GI50 で抗増殖活性を示します。
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Cas No.: 1817802-18-8
Sample solution is provided at 25 µL, 10mM.
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MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM[1].
[1]. Han-Li Huang, et al. TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Theranostics. 2019 Sep 18;9(22):6676-6689.
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