MSC1094308 |
| カタログ番号GC60257 |
MSC1094308 は非競合的で可逆的な VPS4B/p97 (VCP) (I/II タイプ AAA ATPase) アロステリック阻害剤で、VPS4B と p97 の IC50 値はそれぞれ 0.71 μM と 7.2 μM です。 MSC1094308 は、p97 のドラッグ可能なホットスポットに結合することにより、D2 ATPase 活性を阻害します。 MSC1094308 は、がんの研究に使用できます。
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Cas No.: 2219320-08-6
Sample solution is provided at 25 µL, 10mM.
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].
[1]. PÖhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
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