GNE 0723 |
カタログ番号GC31270 |
GNE 0723は、GluN2Aについて21nM、GluN2CおよびGluN2Dについてそれぞれ7.4および6.2μMのEC50を有する、NMDARの脳透過性ポジティブアロステリック調節因子である。
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Cas No.: 1883518-31-7
Sample solution is provided at 25 µL, 10mM.
GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.
GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].
[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
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