Oxatomide |
| カタログ番号GC61401 |
オキサトミドは、抗ヒスタミンおよび抗アレルギー活性を有する、強力で経口的に活性なデュアル H1-ヒスタミン受容体および P2X7 受容体アンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60607-34-3
Sample solution is provided at 25 µL, 10mM.
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Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2].
[1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.
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