PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC50 of 0.074 μM [1].
In Vitro, PHD-1-IN-4 (Compound 39) potently inhibits purified PHD-1 enzyme with an IC50 of 0.074 μM[1].
References:
[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672.
In Vitro, PHD-1-IN-4 (Compound 39) potently inhibits purified PHD-1 enzyme with an IC50 of 0.074 μM[1].
References:
[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672.