PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ). PI3K/mTOR ligand-1 can be used to synthesize GP262 [1].
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
[1]. Zhu W, et al. Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway. J Med Chem. 2025 Dec 25;68(24):26188-26205.
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
[1]. Zhu W, et al. Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway. J Med Chem. 2025 Dec 25;68(24):26188-26205.