Poly-L-lysine (M.W 70000~150000) |
カタログ番号GC19601
One-Click Copy Product Info
|
Poly-L-lysine (M.W 70000~150000) is a polymer consists of numerous L-lysine with great biocompatibility.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 25988-63-0
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Poly-L-lysine (M.W 70000~150000) is a polymer consists of numerous L-lysine with great biocompatibility [1]. Poly-L-lysine shows a wide range of antimicrobial activity and is stable at high temperatures and under both acidic and alkaline conditions[2]. The mechanism of the inhibitory effect of Poly-L-lysine on microbial growth is the electrostatic adsorption to the cell surface of microorganisms on the basis of the poly-cationic property [2]. Poly-L-lysine has effectively been used to adhere biological material such as human red blood cells, mouse leukemic cells, and marine dinoflagellates to glass coverslips[3]. Poly-L-lysine has been widely used as a coating material for porous biomass carrier particles to increase the density of immobilized Escherichia coli cells[4]. Poly-L-lysine is widely used in imaging identification and bio-silicification, not only as antimicrobial or antiviral drug carriers of proteins, and nucleic acids but also as adjuvants, modifiers, temples, or catalysts for certain drugs [5].
References:
[1] Stagi L, Sini M, Carboni D, et al. Modulating the poly-l-lysine structure through the control of the protonation–deprotonation state of l-lysine[J]. Scientific Reports, 2022, 12(1): 19719.
[2] Yoshida T, Nagasawa T. ε-Poly-l-lysine: microbial production, biodegradation and application potential[J]. Applied microbiology and biotechnology, 2003, 62(1): 21-26.
[3] Botes L, Price B, Waldron M, et al. A simple and rapid scanning electron microscope preparative technique for delicate “gymnodinioid” dinoflagellates[J]. Microscopy research and technique, 2002, 59(2): 128-130.
[4] Huang J, Yamaji H, Fukuda H. Immobilization of Escherichia coli cells using porous support particles coated with cationic polymers[J]. Journal of bioscience and bioengineering, 2007, 104(2): 98-103.
[5] Chen S, Huang S, Li Y, et al. Recent advances in epsilon-poly-L-lysine and L-lysine-based dendrimer synthesis, modification, and biomedical applications[J]. Frontiers in Chemistry, 2021, 9: 659304.
| Cas No. | 25988-63-0 | SDF | |
| Formula | M.Wt | 70000~150000 | |
| 溶解度 | Storage | Store at -20°C, stored under nitrogen | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 14.3 μL | 71.4 μL | 142.9 μL |
| 5 mM | 2.9 μL | 14.3 μL | 28.6 μL |
| 10 mM | 1.4 μL | 7.1 μL | 14.3 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)