SK 609 |
| カタログ番号GC50644 |
ドーパミンD3受容体バイアス作動薬
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1092797-77-7
Sample solution is provided at 25 µL, 10mM.
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Dopamine D3 receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC50 values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D3 over D2 receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA induced abnormal involuntary movements.
Xu et al (2017) Functional characterization of a novel series of biased signaling dopamine D3 receptor agonists. ACS Chem.Neurosci. 8 486 PMID:27801563 |Simms et al (2016) In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease. Neuropharmacology 100 106 PMID:25896768
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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