Ascochlorin (Synonyms: Antibiotic LL-Z1272γ, Ilicicolin D, NSC 287492) |
| Catalog No.GC40715 |
이소프레노이드 항생제인 Ascochlorin(Ilicicolin D)은 주로 STAT3 신호 전달 캐스케이드의 억제를 통해 항종양 효과를 매개합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26166-39-2
Sample solution is provided at 25 µL, 10mM.
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Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of matrix metalloproteinase-9. At 2 µM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 µm, it inhibits signaling through STAT3. Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.
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