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CETP

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CETP (cholesteryl ester transfer protein) is a hydrophobic glycoprotein consisting of 476 amino acids residue that, in general, facilitates the transfer of neutral lipids (such as cholesteryl and triglycerides) among lipoprotein particles. The chemical structure of CETP takes on a shape of a boomerang in which a long hydrophobic tunnel with openings at either end allows lipids to be exchanged between donor and acceptor lipoproteins in a non-aqueous phase. Study results suggest that CETP facilitates the transfer of cholesteryl esters from HDL to LDL and VLDL resulting in the lowering of HDL levels and raising of LDL and VDL levels, which might increase the risk of cardiovascular disease.

Products Related to CETP(11)

  • GC13856 structure
    GC13856Dalcetrapib (JTT-705, RO4607381)
    CAS: 211513-37-0
    Purity: >99.00%

    An inhibitor of cholesteryl ester transfer protein

  • GC14061 structure
    GC14061Evacetrapib (LY2484595)
    CAS: 1186486-62-3
    Purity: >99.00%

    A CETP inhibitor

  • GC15848 structure
    GC15848Torcetrapib
    CAS: 262352-17-0
    Purity: >99.00%

    A CETP inhibitor

  • GC17520 structure
    GC17520Anacetrapib (MK-0859)
    CAS: 875446-37-0
    Purity: >99.50%

    A CETP inhibitor

  • GC35657 structure
    GC35657CETP-IN-3
    CAS: 939391-31-8
    Purity: >98%

    CETP-IN-3(화합물 13)은 혈장 당단백질 콜레스테롤 에스테르 전달 단백질(CETP)의 소분자 억제제로, CETP의 억제를 통해 HDL-C를 상승시킵니다.

  • GC37736 structure
    GC37736TAP311
    CAS: 1149362-88-8
    Purity: >98%

    TAP311은 IC50이 62nM인 콜레스테릴 에스테르 전달 단백질(CETP) 억제제입니다.

  • GC38759 structure
    GC38759CP-532623
    CAS: 261947-38-0
    Purity: >98%

    CP-532623은 CETP 억제제이며 고밀도 지단백 콜레스테롤 수치를 높입니다.

  • GC50257 structure
    GC50257BMS 795311
    CAS: 939390-99-5
    Purity: >98%

    BMS 795311은 효소 기반 섬광 근접 분석(SPA)에서 IC50이 4nM이고 인간 전체 혈장 분석(hWPA)에서 각각 0.22μM인 콜레스테릴 에스테르 전달 단백질(CETP)의 강력하고 경구 생체이용 가능한 억제제입니다.

  • GC68876 structure
    GC68876CKD-519
    CAS: 1402796-27-3
    Purity: >99.00%

    CKD-519는 효과적인 선택적 콜레스테롤 에스터 전이 단백질(CETP) 억제제입니다. CKD-519는 CETP 매개 인간 혈청 내의 콜레스테롤 에스터 전이를 억제하며, IC50 값은 2.3 nM입니다.

  • GC79585 structure
    GC79585UBA6-IN-1
    CAS: 1557137-61-7
    Purity: >99.00%

    UBA6-IN-1 is a UBA6/UBE1L2 inhibitor ( IC 50 ≤50 nM) that acts by reducing the level of squalene epoxidase ( SQLE ).

  • GC81860 structure
    GC81860UBA6-IN-1 hydrochloride
    CAS: 1557138-61-0
    Purity: >98.00%

    UBA6-IN-1 hydrochloride is a UBA6/UBE1L2 inhibitor ( IC 50 ≤50 nM) that acts by reducing the level of squalene epoxidase ( SQLE ).