BMS 795311 |
| Catalog No.GC50257 |
BMS 795311은 효소 기반 섬광 근접 분석(SPA)에서 IC50이 4nM이고 인간 전체 혈장 분석(hWPA)에서 각각 0.22μM인 콜레스테릴 에스테르 전달 단백질(CETP)의 강력하고 경구 생체이용 가능한 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939390-99-5
Sample solution is provided at 25 µL, 10mM.
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Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:26524347
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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