DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG2000-iRGD can be used for agent delivery [1].
In Vitro, DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties[1]. M-SAL-iRGD (iRGD-conjugated DSPE-PEG2000 nanomicelles) constructed with DSPE-PEG2000-iRGD are used for targeted delivery of Salinomycin to intervene in liver cancer cells and cancer stem cells[2]. iRGD-LP-CUR-PIP, constructed with DSPE-PEG2000-iRGD, is a tumor-penetrating peptide liposome that exhibits antitumor effects, mainly manifested in a significant reduction in tumor volume and an increase in body weight and spleen index[3].
References:
[1]. Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74.
[2]. Mao X, et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells. Nanomedicine (Lond). 2015;10(17):2677-95.
[3]. Wang Y, et al. The Antitumour Activity of a Curcumin and Piperine Loaded iRGD-Modified Liposome: In Vitro and In Vivo Evaluation. Molecules. 2023 Sep 9;28(18):6532.
In Vitro, DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties[1]. M-SAL-iRGD (iRGD-conjugated DSPE-PEG2000 nanomicelles) constructed with DSPE-PEG2000-iRGD are used for targeted delivery of Salinomycin to intervene in liver cancer cells and cancer stem cells[2]. iRGD-LP-CUR-PIP, constructed with DSPE-PEG2000-iRGD, is a tumor-penetrating peptide liposome that exhibits antitumor effects, mainly manifested in a significant reduction in tumor volume and an increase in body weight and spleen index[3].
References:
[1]. Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74.
[2]. Mao X, et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells. Nanomedicine (Lond). 2015;10(17):2677-95.
[3]. Wang Y, et al. The Antitumour Activity of a Curcumin and Piperine Loaded iRGD-Modified Liposome: In Vitro and In Vivo Evaluation. Molecules. 2023 Sep 9;28(18):6532.