Emixustat hydrochloride (ACU-4429 hydrochloride) (Synonyms: ACU-4429 hydrochloride) |
| Catalog No.GC33763 |
에믹서스타트 염산염(ACU-4429 염산염)은 232 ±의 IC50 값으로 11-시스-레티놀 생성을 강력하게 억제합니다. 3nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1141934-97-5
Sample solution is provided at 25 µL, 10mM.
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Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. IC50 value: 232 nM [1]Target: 11-cis-retinolEmixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe and well tolerated when administered once daily for 14 days with minimal systemic adverse events reported. Evaluation of emixustat in subjects with geographic atrophy associated with dry age-related macular degeneration.[2]
[1]. Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. [2]. Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9.
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