Busulfan (Synonyms: Busulphan, Mielosan, Milecitan, Myeloleukon, Mylecytan, Myleran, NCI C01592, NSC 750) |
| Catalog No.GC13671 |
Busulfan은 골수에 선택적 면역억제 효과가 있는 강력한 알킬화제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55-98-1
Sample solution is provided at 25 µL, 10mM.
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Busulfan is a DNA alkylating agent [1].
DNA alkylating agent is attached to the guanine base of DNA and stops tumor growth by crosslinking guanine nucleobases in DNA double-helix strands and causes DNA damage [1].
In normal human diploid WI38 fibroblasts, busulfan (7.5-120 μM) induced senescence in a dose-dependant way, which was associated with prolonged activation of c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38) and extracellular signal-regulated kinase (Erk) [2]. The induction of senescence was initiated by the transient depletion of intracellular glutathione (GSH) and then an increase in reactive oxygen species (ROS) production, which activated the Erk and p38 MAPK pathway [1].
In the adult mouse testis, busulfan induced apoptosis and decreased testis weight. In the first week, apoptosis mainly occured to spermatogonia. In the following week, spermatogonia-specific markers Stra 8 and c-kit were reduced but Gli I remained constant, which indicated apoptosis of differentiating type A spermatogonia [3].
References:
[1]. Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med, 2007, 42(12): 1858-1865.
[2]. Probin V, Wang Y, Bai A, et al. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism. J Pharmacol Exp Ther, 2006, 319(2): 551-560.
[3]. Choi YJ, Ok DW, Kwon DN, et al. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett, 2004, 575(1-3): 41-51.
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