Eplerenone (Synonyms: CGP 30083, (+)-Eplerenone, Epoxymexrenone, SC-6110, SC-66110) |
| Catalog No.GC15831 |
Eplerenone(Epoxymexrenone)은 선택적이고 고도로 특이적인 구강 활성 알도스테론 차단제(SAB)입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 107724-20-9
Sample solution is provided at 25 µL, 10mM.
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Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2].
References:
[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25.
[2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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