WDR5-IN-4 TFA |
| Catalog No.GC61380 |
WDR5-IN-4 TFA는 0.1nM의 Kd를 갖는 염색질 관련 WD 반복 함유 단백질 5(WDR5)의 WIN 부위 억제제입니다. WDR5-IN-4 TFA는 염색질에서 WDR5를 대체하고 관련 유전자의 발현을 감소시켜 번역 억제, 핵 스트레스를 유발합니다. 항암 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
[1]. Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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