GLP-2 (1-34) (human) is a synthetic form of the human peptide GLP-2 that contains the full human sequence with the addition of an arginine residue at the C-terminal end.1 It increases survival of myenteric neurons cultured alone (EC50 = 0.35 nM) and when co-cultured with mast cells to induce cell death.2 It does not stimulate insulin release from isolated rat pancreatic islets in the presence of glucose when used at concentrations ranging from 2.5 to 250 nM.1 GLP-2 (1-34) (human) also does not affect formation of adenomas in a transgenic model of intestinal tumorigenesis using ApcMin/+ mice.3
References
1. Schmidt, W.E., Siegel, E.G., and Creutzfeldt, W. Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 28(9), 704-707 (1985).
2. Voss, U., Sand, E., Hellstr•m, P.M., et al. Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons. BMC Gastroenterol. 12, 30 (2012).
3. Koehler, J.A., Harper, W., Barnard, M., et al. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 68(19), 7897-7904 (2008).