HCV Protease
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Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
Products Related to HCV Protease(37)
- GC14074NarlaprevirCAS: 865466-24-6Purity: >98.00%
Narlaprevir는 높은 선택성과 경구 활성을 가진 C형 간염 바이러스 비구조 단백질 3(HCV NS3) 억제제로 Ki 값은 6 nM이고 EC90 값은 40 nM이다.
- GC17701Clemizole hydrochlorideCAS: 1163-36-6Purity: >99.50%
An antihistamine and TRPC5 channel blocker
- GC19165GlecaprevirCAS: 1365970-03-1Purity: >98.00%
글레카프레비르는 HCV NS3/4A 프로테아제 억제제로, IC50 값은 3.5에서 11.3 nM 범위 내에 있습니다.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC12057 | Daclatasvir (BMS-790052) | 1214735-16-6 | >98% | |
HCV NS5A inhibitor | ||||
| GC10155 | Vaniprevir | 923590-37-8 | >98% | |
| GC10832 | VX-222 (VCH-222, Lomibuvir) | 1026785-59-0 | >98% | |
An HCV polymerase inhibitor | ||||
| GC10930 | Balapiravir | 690270-29-2 | >98% | |
| GC10959 | Boceprevir | 394730-60-0 | >98.00% | |
An NS3/4A protease inhibitor | ||||
| GC11463 | MK-5172 sodium salt | 1425038-27-2 | >98% | |
| GC11840 | Ciluprevir (BILN-2061) | 300832-84-2 | >98% | |
Inhibitor of HCV NS3 protease | ||||
| GC12236 | Daclatasvir dihydrochloride | 1009119-65-6 | >99.50% | |
An NS5A inhibitor | ||||
| GC12299 | Telaprevir (VX-950) | 402957-28-2 | >98.00% | |
An HCV NS3/4A protease inhibitor | ||||
| GC12444 | Clemizole | 442-52-4 | >98% | |
An antihistamine and TRPC5 channel blocker | ||||
| GC12879 | Danoprevir (RG7227) | 850876-88-9 | >99.50% | |
An HCV NS3/4A protease inhibitor | ||||
| GC13312 | HZ-1157 | 1009734-33-1 | >98.50% | |
HZ-1157은 1.0μmol/L의 IC50으로 HCV NS3/4A 프로테아제를 억제합니다. | ||||
| GC14074 | Narlaprevir | 865466-24-6 | >98.00% | |
Narlaprevir는 높은 선택성과 경구 활성을 가진 C형 간염 바이러스 비구조 단백질 3(HCV NS3) 억제제로 Ki 값은 6 nM이고 EC90 값은 40 nM이다. | ||||
| GC14458 | Asunaprevir (BMS-650032) | 630420-16-5 | >99.50% | |
An HCV NS3/4A protease inhibitor | ||||
| GC14937 | Anguizole | 442666-98-0 | >99.50% | |
| GC15891 | Nesbuvir | 691852-58-1 | >98.50% | |
| GC16098 | MK-5172 hydrate | 1350462-55-3 | >99.00% | |
| GC16887 | Tegobuvir | 1000787-75-6 | >98.00% | |
A non-nucleoside inhibitor of HCV NS5B | ||||
| GC16901 | PSI-6206 | 863329-66-2 | >99.50% | |
An inactive derivative of a HCV NS5B inhibitor | ||||
| GC17114 | MK-5172 potassium salt | 1206524-86-8 | >99.00% | |
| GC17270 | Simeprevir | 923604-59-5 | >99.50% | |
A potent NS3/4A protease inhibitor | ||||
| GC17701 | Clemizole hydrochloride | 1163-36-6 | >99.50% | |
An antihistamine and TRPC5 channel blocker | ||||
| GC18004 | MK-5172 | 1350514-68-9 | >99.50% | |
MK-5172는 C형 간염 바이러스(HCV) NS3/4a 프로테아제의 선택적 억제제로 다양한 유전형 및 약물 내성 변이에 대해 광범위한 활성을 나타내고 SARS-CoV-2 3CL 프로테아제 활성을 억제할 수 있다. | ||||
| GC19165 | Glecaprevir | 1365970-03-1 | >98.00% | |
글레카프레비르는 HCV NS3/4A 프로테아제 억제제로, IC50 값은 3.5에서 11.3 nM 범위 내에 있습니다. | ||||