HS-10296 |
| Catalog No.GC39560 |
HS-10296(HS-10296)은 EGFR-민감성 및 T790M 내성 돌연변이에 대해 높은 선택성을 갖는 경구용 비가역 3세대 EGFR 티로신 키나제 억제제입니다. HS-10296은 T790M, T790M/L858R, T790M/Del19(IC50: 각각 0.37, 0.29, 0.21 nM)에 대해 큰 억제 활성을 보이며, 야생형(3.39 nM)에 대해서는 덜 효과적이다. HS-10296은 비소세포폐암 연구에 사용된다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1899921-05-1
Sample solution is provided at 25 µL, 10mM.
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HS-10296, an orally available and third-generation EGFR-activating mutations and T790M-resistant mutation inhibitor, shows limited activity against wild-type EGFR[1][2].
[1]. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76. [2]. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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