IA107 is a potent, selective, and allosteric IRE1α RNase ( IC50 = 16 nM (non phosphorylated), IC50 = 9 nM (phosphorylated)) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity [1].
References:
[1]. Liu Y, et al. Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. Nat Commun. 2025 Sep 26;16(1):8531.
References:
[1]. Liu Y, et al. Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. Nat Commun. 2025 Sep 26;16(1):8531.