>>Peptides>>Influenza Hemagglutinin (HA) Peptide

Influenza Hemagglutinin (HA) Peptide

카탈로그 번호: GP10152

인플루엔자 혈구응집소(HA) 펩타이드(HA 태그)는 인간 인플루엔자 혈구응집소(HA)에서 파생된 9개 아미노산 펩타이드입니다.

Influenza Hemagglutinin (HA) Peptide 화학 구조

Size 가격 재고 수량
10mM (in 1mL DMSO)
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Sample solution is provided at 25 µL, 10mM.

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HA tag,Complexes containing plasmid DNA, transferrin-polylysine conjugates, and polylysine-conjugated peptides derived from the N-terminal sequence of the influenza virus hemagglutinin subunit HA-2 have been used for the transfer of luciferase or -galactosidase marker genes to K562 cells, HeLa cells, and BNL CL.2 hepatocytes. The presence of these influenza peptide conjugates in the DNA complexes renders the complexes active in membrane disruption in a liposome leakage assay and results in a substantial augmentation of the transferrin-polylysine-mediated gene transfer.
Fusogenic peptides derived from the N-terminal sequence of the influenza virus hemagglutinin subunit HA-2 is part of the DNA complexes and the resulting augmentation of gene transfer to cultured cells1.
In the influenza virus, the hemagglutinin (HA) protein mediates both binding of the virus to the cell surface and the subsequent fusion of viral and cellular membranes. HA is composed of a receptor-binding subunit, denoted HA1, and a fusogenic subunit, denoted HA2. The native HA1yHA2 complex, as found on the surface of the native virus, is fusioninactive. For influenza virus, membrane fusion is regulated by the conformational state of the hemagglutinin (HA) protein, which switches from a native (nonfusogenic) structure to a fusion-active (fusogenic) conformation when exposed to the acidic environment of the cellular endosome. The native structure of HA is trapped in a metastable state and that the fusogenic conformation is released by destabilization of native structure2.

1. E. WAGNER, C. PLANK et al, Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle. Proc. Nati. Acad. Sci. USA Vol. 89, pp. 7934-7938, September 1992
2. C. M. CARR, C. CHAUDHRY, P. S. KIM et al. Influenza hemagglutinin is spring-loaded by a metastable native conformation. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 14306–14313

화학적 특성

Cas No. 92000-76-5 SDF
동의어 H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-OH
Chemical Name Influenza Hemagglutinin (HA) Peptide
Formula C53H67N9O17 M.Wt 1102.15
용해도 ≥ 55.1075mg/mL in DMSO, ≥ 100.4 mg/mL in EtOH, ≥ 46.2 mg/mL in Water Storage Desiccate at -20°C
일반적인 팁 높은 용해도를 얻기 위해 튜브를 37℃에서 데운 후 초음파 욕조에서 잠시 흔들어 주십시오. 원액은 -20℃ 이하에서 수개월간 보관할 수 있습니다.
배송 조건 평가 샘플 솔루션: 블루아이스와 함께 배송합니다. 다른 모든 가능한 크기: 요청 시 RT 또는 블루아이스와 함께 배송합니다.

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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**원액을 준비할 때는 항상 바이알 라벨과 MSDS/CoA(온라인에서 사용 가능)에 있는 제품의 배치별 분자량을 사용하십시오.



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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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