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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC10451 structure
    GC10451U-73122
    CAS: 112648-68-7
    Purity: >98.00%

    U-73122은 IC50 값이 약 1-2.1μM인 강력하고 선택적인 인지질효소 C（PLC） 억제제이다. 게다가 5-lipoxygenase (5-LO) 을 억제한다.

  • GC10821 structure
    GC1082111-keto-β-Boswellic Acid
    CAS: 17019-92-0
    Purity: >99.50%

    11-Keto-beta-boswellic acid(11-Keto-β-boswellic acid)는 인도 유향으로 널리 알려진 Boswellia serrate tree의 껍질에서 추출한 올레오검 수지의 5환형 트리테르펜산입니다. 11-Keto-beta-boswellic acid는 주로 5-lipoxygenase(5-LOX) 및 후속 류코트리엔 및 핵 인자-카파 B(NF-κB) 활성화 및 종양 괴사 인자 알파 생성을 억제하기 때문에 항염증 활성이 있습니다. 생산.

  • GC12661 structure
    GC12661Indirubin-3'-oxime
    CAS: 160807-49-8
    Purity: >99.00%

    인디루빈-3'-옥심은 강력한 GSK-3β입니다. 각각 22nM 및 7.8-10 μM의 IC50으로 5-리폭시게나제를 억제하고 약하게 억제합니다. 인디루빈-3'-옥심은 또한 100 및 180 nM의 IC50으로 CDK5/p25 및 CDK1/사이클린 B에 대한 억제 활성을 나타냅니다.

  • GC14435 structure
    GC14435Zileuton sodium
    CAS: 118569-21-4
    Purity: >98%

    질류톤 나트륨(A 64077 나트륨)은 5-리폭시게나제의 강력하고 선택적인 억제제로 염증 활성을 나타냅니다.

  • GC14751 structure
    GC14751Malotilate
    CAS: 59937-28-9
    Purity: >99.50%

    말로틸레이트(NKK 105), 경구 활성 간기능 강화제 및 항섬유화 물질은 5-리폭시게나제(5-LOX)(IC50=4.7μM)를 선택적으로 억제합니다. Malotilate는 간의 아세트알데히드 수치를 감소시키고 간세포에서 트랜스페린의 체류를 방지함으로써 알코올-피라졸 간염에서 간세포 손상의 발병을 예방합니다.

  • GC14847 structure
    GC14847Psoralidin
    CAS: 18642-23-4
    Purity: >98.00%

    소라리딘은 COX-2 및 5-LOX의 이중 억제제이며 이온화 방사선(IR) 유발 폐 염증을 조절합니다. 항암, 항박테리아 및 항염증 특성. 소라리딘은 NOTCH1 신호전달을 상당히 하향조절합니다. Psoralidin은 또한 ROS 생성을 크게 유도합니다.

  • GC16014 structure
    GC16014Zileuton
    CAS: 111406-87-2
    Purity: >99.00%

    Zileuton은 벤조티오펜 N-하이드록시우레아이고 구강용 5-리포옥시젠레이스 억제제이다.

  • GC18089 structure
    GC18089Nordihydroguaiaretic acid
    CAS: 500-38-9
    Purity: >97.00%

    Nordihydroguaiaretic acid is a potent 5-lipoxygenase (5-LOX) inhibitor with an IC 50 value of 8μM.

  • GC18480 structure
    GC18480CAY10649
    CAS: 1272519-89-7
    Purity: >98%

    5-Lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, which are involved in a variety of inflammatory responses, including neutrophil chemotaxis, vascular permeability, and smooth muscle contraction.

  • GC18552 structure
    GC18552Lipoxin A4
    CAS: 89663-86-5
    Purity: >95.00%

    공액된 테트라엔을 포함하는 삼수산화 지방산

  • GC18680 structure
    GC18680Lipoxin A4 methyl ester
    CAS: 97643-35-1
    Purity: >95.00%

    Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4.

  • GC18681 structure
    GC18681Lipoxin B4
    CAS: 98049-69-5
    Purity: >95.00%

    Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes.

  • GC18688 structure
    GC18688CAY10589
    CAS: 1077626-52-8
    Purity: >98%

    Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain.

  • GC18728 structure
    GC18728CJ-13610
    CAS: 179420-17-8
    Purity: >98%

    비산화환원형 5-LO 억제제인 \u200b\u200bCJ-13610은 IC50이 약 70nM인 외인성 AA가 없는 상태에서 이온통로단 A23187로 자극된 PMNL에서 5-LO 생성물 형성을 용량 의존적으로 억제한다.

  • GC18835 structure
    GC18835Leukotriene A4 methyl ester
    CAS: 73466-12-3
    Purity: >97.00%

    Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities.

  • GC18845 structure
    GC18845Leukotriene F4
    CAS: 83851-42-7
    Purity: >97.00%

    류코트리엔 F4(LTF4)는 시스테이닐 류코트리엔(CysTL) 계열에 속하는 지질입니다.

  • GC18877 structure
    GC18877CAY10606
    CAS: 1159576-98-3
    Purity: >98%

    5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations.

  • GC19460 structure
    GC194609(S)-HODE
    CAS: 73543-67-6
    Purity: >98.00%

    9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.

  • GC19462 structure
    GC1946213(R)-HODE
    CAS: 10219-69-9
    Purity: >98.00%

    13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase.

  • GC19463 structure
    GC1946313(S)-HODE
    CAS: 29623-28-7
    Purity: >98.00%

    13(S)-HODE (13(S)-HODE)는 리놀레산의 15-lipoxygenase (15-LOX) 대사 산물로 PPARγ를 활성화하는 내인성 리간드로 기능한다.

  • GC19474 structure
    GC1947413(S)-HpODE
    CAS: 33964-75-9
    Purity: >95.00%

    13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals.

  • GC19933 structure
    GC19933Leukotriene B4
    CAS: 71160-24-2
    Purity: >95.00%

    류코트리엔 B4(LTB4)는 가장 강력한 화학 유인 물질 및 백혈구 활성제 중 하나로 알려져 있으며 염증성 질환에 관여합니다.

  • GC26233 structure
    GC26233Docosahexaenoic Acid-d5
    CAS: 1197205-71-2
    Purity: >99.00%

    Docosahexaenoic acid-d5 (DHA-d5) is intended for use as an internal standard for the quantification of DHA (Item No. 90310) by GC- or LC-MS.

  • GC30027 structure
    GC30027S-(+)-Marmesin ((+)-Marmesin)
    CAS: 13849-08-6
    Purity: >98.00%

    S-(+)-Marmesin((+)-Marmesin)은 COX-2/5-LOX 이중 억제 활성을 나타내는 천연 쿠마린입니다.