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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC49894 structure
    GC4989415(S)-HETE-d8 ethyl ester
    Purity: >99.00%

    An internal standard for the quantification of 15(S)-HETE ethyl ester

  • GC52105 structure
    GC52105Montelukast
    CAS: 158966-92-8
    Purity: >99.00%

    Montelukast(MK0476 유리 염기)는 시스테닐 류코트리엔 수용체 1(CysLT1)의 강력하고 선택적이며 경구 활성 길항제입니다.

  • GC52413 structure
    GC524135-Aminosalicylic Acid-d7
    Purity: >99.00%

    An internal standard for the quantification of 5-aminosalicylic acid

  • GC61180 structure
    GC61180Phenidone
    CAS: 92-43-3
    Purity: >98.00%

    cyclooxygenase(COX)와 lipoxygenase(LOX)의 경구 활성 이중 억제제인 Phenidone은 실험적인 자가면역 뇌척수염에서 쥐의 마비를 개선합니다.

  • GC62040 structure
    GC62040Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
    CAS: 132465-11-3
    Purity: >99.50%

    Cinnamyl-3,4-dihydroxy-α-cyanocinnamate(CDC)는 강력한 12/15-Lipoxygenases(LO) 억제제입니다.

  • GC64078 structure
    GC640783-O-Acetyl-11-hydroxy-beta-boswellic acid
    CAS: 146019-25-2
    Purity: >98.00%

    3-O-아세틸-11-하이드록시-베타-보스웰산은 강력한 5-리폭시게나제(5-LO) 억제제입니다.

  • GC64621 structure
    GC646214-Nitrocatechol
    CAS: 3316-09-4
    Purity: >98%

    4-Nitrocatechol은 강력한 리폭시게나제 억제제입니다.

  • GC66031 structure
    GC660315-LOX-IN-1
    CAS: 55040-82-9
    Purity: >98.00%

    5-LOX-IN-1(화합물 2b)은 IC50 값이 2.3 μ인 인간 5-Lipoxygenase(5-LOX)의 억제제입니다. 821d96072c2d58d8970e76f526b0f6b85-LOX-IN-1은 염증 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8

  • GC68641 structure
    GC68641ALOX15-IN-1
    Purity: >98.00%

    ALOX15-IN-1 (화합물 8b)은 유인과 인간 ALOX15 아연효소 (linoleate oxygenase) 활성을 효과적이고 선택적으로 억제하는 화합물로, ALOX15 직계 동종체 아연효소인 리놀레산(LA) 및 아라키돈산(AA)의 IC50 값은 각각 0.04 및 2.06 μM입니다.

  • GC69335 structure
    GC69335KKII5
    CAS: 6381-55-1
    Purity: >98.00%

    KKII5는 유효한 지질 산화 효소 LOX-1 억제제로, IC50 값은 19 μM입니다. KKII5는 지질 과산화를 억제합니다.

  • GC69434 structure
    GC69434Masoprocol
    CAS: 27686-84-6
    Purity: >99.00%

    Masoprocol (meso-Nordihydroguaiaretic acid) is an effective and orally active inhibitor of lipoxygenase. Masoprocol has shown anti-hyperglycemic activity by reducing glucose levels and liver triglyceride concentrations in the body. Masoprocol has potential for researching type II diabetes.

  • GC70263 structure
    GC70263Tebufelone
    CAS: 112018-00-5
    Purity: >99.00%

    Tebufelone (NE - 11740) 는 비스테로이드 항염제 (NSAID) 로 선택적 이중 COX - 2 / 5 - 지산화 효소 억제제입니다.

  • GC70448 structure
    GC70448MLS000545091
    CAS: 322666-76-2
    Purity: >99.00%

    MLS000545091 는 h15-LOX-2에 대한 IC50 값이 2.6 μM인 효과적인 선택적 지산화 효소-2 (LOX-2) 억제제입니다.

  • GC72794 structure
    GC72794Flobufen
    CAS: 112344-52-2

    Flobufen (VUFB 16066) 는 비스테로이드 항염증제와 환산화효소(COX) 및 5-지산화효소(5-LOX) 억제제의 일종이다.

  • GC74159 structure
    GC74159MK-0731
    CAS: 845256-65-7
    Purity: >99.00%

    MK-0731 는 IC50이 2.2nM, pKa가 7.6인 선택적이고 비경쟁적이며 변형된 구동 단백질인 방추체 단백질(KSP) 억제제이다.

  • GC79706 structure
    GC797065-LOX-IN-9
    CAS: 2668-47-5
    Purity: >98.00%

    5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC 50 of 0.2 pM against guinea pig 5-LOX and an IC 50 of 0.7 pM against bovine COX.

  • GC79757 structure
    GC79757ALOX5 stabilizer-1 TFA
    Purity: >98.00%

    ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC90533 structure
    GC90533(-)-Pinoresinol
    CAS: 81446-29-9
    Purity: >95.00%

    다양한 생물학적 활동을 가진 리그난

  • GC90652 structure
    GC9065212-oxo-9(Z)-Dodecenoic Acid
    CAS: 60485-39-4
    Purity: >95.00%

    리놀레산과 리놀렌산의 대사 생성물

  • GC91594 structure
    GC91594LYS-006 (hydrochloride)
    CAS: 2619563-79-8
    Purity: >98.00%

    LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.

  • GC91613 structure
    GC91613FerroLOXIN-1
    CAS: 2773428-48-9
    Purity: >90.00%

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

  • GN10269 structure
    GN10269Wedelolactone
    CAS: 524-12-9
    Purity: >99.50%
  • GN10792 structure
    GN10792Caffeic acid
    CAS: 331-39-5
    Purity: >98.50%

    Caffeic acid is a hydroxycinnamic acid polyphenol compound with antioxidant activity. Caffeic acid is an inhibitor of TRPV1 ion channel and 5-lipoxygenase.