Lipoxygenase
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Targets for Lipoxygenase
Products for Lipoxygenase
- Cat.No. 상품명 정보
- GC48993 Protectin D1-d5 An internal standard for the quantification of protectin D1
- GC14847 Psoralidin 소라리딘은 COX-2 및 5-LOX의 이중 억제제이며 이온화 방사선(IR) 유발 폐 염증을 조절합니다. 항암, 항박테리아 및 항염증 특성. 소라리딘은 NOTCH1 신호전달을 상당히 하향조절합니다. Psoralidin은 또한 ROS 생성을 크게 유도합니다.
- GC48035 RCTR1 A specialized pro-resolving mediator
- GC41230 Resolvin D1 methyl ester Resolvin D1 메틸 에스테르(RvD1 메틸 에스테르)는 Resolvin D1의 메틸 에스테르입니다.
- GC48041 Resolvin D1-d5 An internal standard for the quantification of RvD1
- GC41231 Resolvin D2 methyl ester Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase.
- GC48042 Resolvin D2-d5 An internal standard for the quantification of RvD2
- GC41232 Resolvin D3 methyl ester Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.
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GC44818
Resolvin D4
Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.
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GC40982
Resolvin D5
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
- GC48972 Resolvin E2 A specialized pro-resolving mediator
- GC48045 Resolvin E4 A specialized pro-resolving mediator
- GC41189 Ricinelaidic Acid Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes).
- GC31813 RWJ 63556 RWJ 63556은 항염증 활성이 있는 경구 활성 COX-2 선택적/5-리폭시게나제 억제제입니다.
- GC30027 S-(+)-Marmesin ((+)-Marmesin) S-(+)-Marmesin((+)-Marmesin)은 COX-2/5-LOX 이중 억제 활성을 나타내는 천연 쿠마린입니다.
- GC31835 S-2474 S-2474는 인간의 온전한 세포에서 COX-2 및 COX-1에 대한 IC50이 11nM 및 27μM인 COX-2 및 5-리폭시게나제(5-LO)의 억제제이며 비스테로이드성 항염증제로 사용됩니다. .
- GC44879 Sclerotiorin Sclerotiorin is a natural product isolated primarily from Penicillium species.
- GC49386 Tepoxalin 테폭살린은 COX와 5-LO(5-lipoxygenase)의 이중 억제제로서 강력한 항염증 활성과 유리한 위장 프로필을 가지고 있습니다.
- GC45024 tetranor-12(S)-HETE 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway.
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GC10451
U-73122
인지자 C, 인지자 A2 및 5-LO의 억제제
- GC41289 U-75302 U-75302는 류코트리엔 B4의 강력한 억제제입니다.
- GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities
- GN10269 Wedelolactone
- GC16014 Zileuton 질류톤은 항천식 특성을 가진 5-리폭시게나제의 강력하고 선택적인 억제제입니다.
- GC14435 Zileuton sodium 질류톤 나트륨(A 64077 나트륨)은 5-리폭시게나제의 강력하고 선택적인 억제제로 염증 활성을 나타냅니다.
- GC48267 Zileuton-d4 An internal standard for the quantification of zileuton