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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC41095 structure
    GC4109512(S)-HpEPE
    CAS: 103239-14-1
    Purity: >96.00%

    12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid.

  • GC41096 structure
    GC4109612-oxo Leukotriene B4
    CAS: 136696-10-1
    Purity: >90.00%

    Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.

  • GC41100 structure
    GC4110014,15-dehydro Leukotriene B4
    CAS: 114616-11-4
    Purity: >97.00%

    Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.

  • GC41101 structure
    GC4110115(S)-HpEPE
    CAS: 125992-60-1
    Purity: >98.00%

    15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid.

  • GC41105 structure
    GC411055(S)-HpEPE
    CAS: 143292-98-2
    Purity: >95.00%

    5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA.

  • GC41107 structure
    GC41107Leukotriene B5
    CAS: 80445-66-5
    Purity: >98.00%

    Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.

  • GC41122 structure
    GC4112212(S)-HpETE
    CAS: 71774-10-2
    Purity: >98.00%

    12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.

  • GC41123 structure
    GC4112312-epi Leukotriene B4
    CAS: 83709-73-3
    Purity: >97.00%

    Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes.

  • GC41124 structure
    GC4112415(S)-HpETE
    CAS: 70981-96-3
    Purity: >95.00%

    15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid.

  • GC41126 structure
    GC411265(S),12(S)-DiHETE
    CAS: 79056-01-2
    Purity: >98.00%

    5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid.

  • GC41127 structure
    GC411275(S),15(S)-DiHETE
    CAS: 82200-87-1
    Purity: >98.00%

    5(S),15(S)-DiHETE는 \5(S),15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC50 of 1.3 μM.en_ko_2021q1.md

  • GC41128 structure
    GC411285(S),6(R)-11-trans DiHETE
    CAS: 129263-59-8
    Purity: >95.00%

    5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor.

  • GC41136 structure
    GC411368(S),15(S)-DiHETE
    CAS: 80234-65-7
    Purity: >98.00%

    8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO.

  • GC41144 structure
    GC4114411-trans Leukotriene C4
    CAS: 74841-69-3
    Purity: >97.00%

    11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4.

  • GC41145 structure
    GC4114514,15-Leukotriene C4
    CAS: 75290-60-7
    Purity: >95.00%

    Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.

  • GC41147 structure
    GC4114711-trans Leukotriene D4
    CAS: 79768-40-4
    Purity: >97.00%

    11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4.

  • GC41148 structure
    GC4114814,15-Leukotriene D4
    CAS: 75290-64-1
    Purity: >97.00%

    14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.

  • GC41149 structure
    GC4114911-trans Leukotriene E4
    CAS: 75715-88-7
    Purity: >97.00%

    11-trans 류코트리엔 E4는 류코트리엔 E4(LTE4)의 이성질체입니다.

  • GC41150 structure
    GC4115014,15-Leukotriene E4
    CAS: 1000852-57-2
    Purity: >97.00%

    Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.

  • GC41189 structure
    GC41189Ricinelaidic Acid
    CAS: 540-12-5
    Purity: >98.00%

    Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes).

  • GC41206 structure
    GC4120614(S)-HDHA
    CAS: 119433-37-3
    Purity: >98.00%

    14(S)-HDHA(14(S)-HDoHE)는 도코사헥사엔산(DHA)의 산소화 생성물입니다.

  • GC41208 structure
    GC4120817(S)-HDHA
    CAS: 92693-03-3
    Purity: >98.00%

    17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.

  • GC41209 structure
    GC4120917-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
    CAS: 1233715-33-7
    Purity: >98%

    Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils.

  • GC41211 structure
    GC41211Anacardic Acid Diene
    CAS: 103904-74-1
    Purity: >95.00%

    Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.