ML 418 |
| Catalog No.GC50596 |
ML 418은 Kir6.2/SUR1을 강력하게 억제하는 Kir7.1 칼륨 채널(IC50, 310 nM)의 최초의 강력하고 선택적인 CNS 침투 차단제이며 다른 Kir 채널보다 우수한 선택성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1928763-08-9
Sample solution is provided at 25 µL, 10mM.
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Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.
Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID:27184474 |Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID:28619748
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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