NBDHEX |
| Catalog No.GC39315 |
NBDHEX는 강력한 글루타티온 S-트랜스퍼라제 P1-1(GSTP1-1) 억제제입니다. NBDHEX는 종양 세포의 세포 사멸을 유도합니다. NBDHEX는 GST의 촉매 활성을 억제하고, 특정 펌프에 의해 세포로부터 억제제가 압출되는 불편을 피하고, GSTP1-1과 주요 신호 작용기 사이의 상호작용을 방해함으로써 항암제 역할을 합니다. NBDHEX는 후기 자가포식 억제제로도 작용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 787634-60-0
Sample solution is provided at 25 µL, 10mM.
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NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor[1][2].
[1]. Sha HH, et al. 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound. Biosci Rep. 2018 Feb 13;38(1). pii: BSR20171440. [2]. Filomeni G, et al. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer. Mol Cancer Ther. 2008 Feb;7(2):371-9. [3]. Pellizzari Tregno F, et al. In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma. Eur J Cancer. 2009 Sep;45(14):2606-17.
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