PKMYT1-IN-8

PKMYT1-IN-8 (Compound 137) is the inhibitor for PKMYT1 with an IC₅₀ of 9 nM. PKMYT1-IN-8 inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2 with IC₅₀ s of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. PKMYT1-IN-8 inhibits the proliferation of cancer cell OVCAR3 with GI 50 of 2.02 μM ^[1].

References:
[1]. Avipsa Ghosh, et al., Pyrrolopyrimidinecarboxamides as PKMYT1 inhibitors and their preparation. WO2024252276.